NOVEL CHRONOTHERAPEUTIC MULTIPARTICULATE DRUG DELIVERY SYSTEM OF FELODIPINE: AN EFFECTIVE TREATMENT FOR CARDIAC ARRHYTHMIA

NOVEL CHRONOTHERAPEUTIC MULTIPARTICULATE DRUG DELIVERY SYSTEM OF FELODIPINE: AN EFFECTIVE TREATMENT FOR CARDIAC ARRHYTHMIA

Arrhythmia follows chronobiology, thus necessitating development of time-dependent formulation for its treatment. The aim of the current work was to develop a solubility-enhanced chronotherapeutic system of felodipine, a widely prescribed anti-arrhythmic. Systematically optimized hot-melt extrusion...

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Bibliographic Details
Main Authors: Sabyasachi Banerjee, K. Ravi Shankar, Y. Rajendra Prasad
Format: Article
Language:English
Published: Universitas Gadjah Mada 2017-01-01
Series:Indonesian Journal of Pharmacy
Subjects:
hot-melt
central composite design
pharmacokinetics
arrhythmia
extrudates
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1159/803

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