GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling

GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling

Summary A significant fraction of mice deficient in either glial cell-derived neurotrophic factor (GDNF) or its co-receptors (Gfrα1, Ret), undergoes ureteric bud (UB) outgrowth leading to the formation of a rudimentary kidney. Previous studies using the isolated Wolffian duct (WD) culture indicate t...

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Bibliographic Details
Main Authors: James B. Tee, Yohan Choi, Ankur Dnyanmote, Marvalyn Decambre, Chiharu Ito, Kevin T. Bush, Sanjay K. Nigam
Format: Article
Language:English
Published: The Company of Biologists 2013-07-01
Series:Biology Open
Subjects:
Ureteric bud
Kidney development
Wolffian duct
AKT
Jun-Fos
JNK signaling
ret
Fibroblast growth factor
Online Access:http://bio.biologists.org/content/2/9/952

Internet

http://bio.biologists.org/content/2/9/952

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