Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication.

Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication.

Any strategy for curing HIV infection must include a method to eliminate viral-infected cells. Based on our earlier proof-of-principle results targeting HIV-1 infected cells with radiolabeled antibody (mAb) to gp41 viral antigen, we embarked on identifying a suitable candidate mAb for preclinical de...

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Bibliographic Details
Main Authors: Ekaterina Dadachova, Scott G Kitchen, Gregory Bristol, Gayle Cocita Baldwin, Ekaterina Revskaya, Cyril Empig, George B Thornton, Miroslaw K Gorny, Susan Zolla-Pazner, Arturo Casadevall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302885?pdf=render

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