Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective

• Main Author: Nicholas V. Vamvakopoulos
• Format: Article
• Language: English
• Published: Hindawi Limited 1995-01-01
• Series: Mediators of Inflammation
• Online Access: http://dx.doi.org/10.1155/S0962935195000275

This review higlghts key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticolds, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/ inflammatory reaction by steroid hormones, from the perspective of the CRH system.