Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines

Abstract Background Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings from in vitro studies of cancer cell lines into in v...

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Bibliographic Details
Main Authors: Yuanyuan Li, David M. Umbach, Juno M. Krahn, Igor Shats, Xiaoling Li, Leping Li
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12864-021-07581-7