Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury

Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury

Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized macrophages are dominant and play a crucial role...

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Bibliographic Details
Main Authors: Xuhui Ge, Pengyu Tang, Yuluo Rong, Dongdong Jiang, Xiao Lu, Chengyue Ji, Jiaxing Wang, Chenyu Huang, Ao Duan, Yang Liu, Xinglin Chen, Xichen Chen, Zhiyang Xu, Feng Wang, Zibin Wang, Xiaoyan Li, Wene Zhao, Jin Fan, Wei Liu, Guoyong Yin, Weihua Cai
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Spinal cord injury
Blood-spinal-cord-barrier
miR-155/SOCS6/p65
Endothelial-to-mesenchymal transition
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172100080X

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