Preparation and antitubercular activity of lipophilic diamines and amino alcohols

Preparation and antitubercular activity of lipophilic diamines and amino alcohols

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity...

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Bibliographic Details
Main Authors: Celso OR Júnior, Mireille Le Hyaric, Cristiane F da Costa, Taís A Corrêa, Aline F Taveira, Débora P Araújo, Elaine FC Reis, Maria Cristina S Lourenço, Felipe RC Vicente, Mauro V de Almeida
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
tuberculosis
amino alcohols
diamines
lipophilicity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500006

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