Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow.
<h4>Background</h4>In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we system...
Main Authors: | Kazuya Iwamoto, Miki Bundo, Junko Ueda, Yoko Nakano, Wataru Ukai, Eri Hashimoto, Toshikazu Saito, Tadafumi Kato |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-12-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0001306 |
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