UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR

Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors,...

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Main Authors: An-Jen Chiang, Chia-Jung Li, Kuan-Hao Tsui, Chung Chang, Yuan-chin Ivan Chang, Li-Wen Chen, Tsung-Hsien Chang, Jim Jinn-Chyuan Sheu
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/1/37
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spelling doaj-4b0a5e8d4b914cdfa9b0bce36346d8562020-12-31T00:00:44ZengMDPI AGBiomolecules2218-273X2021-12-0111373710.3390/biom11010037UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTORAn-Jen Chiang0Chia-Jung Li1Kuan-Hao Tsui2Chung Chang3Yuan-chin Ivan Chang4Li-Wen Chen5Tsung-Hsien Chang6Jim Jinn-Chyuan Sheu7Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Applied Mathematics, National Sun Yat-sen University, Kaohsiung 804, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei 115, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114, TaiwanInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, TaiwanCervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.https://www.mdpi.com/2218-273X/11/1/37UBE2Chuman papillomaviruscervical cancerbioinformation
collection DOAJ
language English
format Article
sources DOAJ
author An-Jen Chiang
Chia-Jung Li
Kuan-Hao Tsui
Chung Chang
Yuan-chin Ivan Chang
Li-Wen Chen
Tsung-Hsien Chang
Jim Jinn-Chyuan Sheu
spellingShingle An-Jen Chiang
Chia-Jung Li
Kuan-Hao Tsui
Chung Chang
Yuan-chin Ivan Chang
Li-Wen Chen
Tsung-Hsien Chang
Jim Jinn-Chyuan Sheu
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
Biomolecules
UBE2C
human papillomavirus
cervical cancer
bioinformation
author_facet An-Jen Chiang
Chia-Jung Li
Kuan-Hao Tsui
Chung Chang
Yuan-chin Ivan Chang
Li-Wen Chen
Tsung-Hsien Chang
Jim Jinn-Chyuan Sheu
author_sort An-Jen Chiang
title UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
title_short UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
title_full UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
title_fullStr UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
title_full_unstemmed UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
title_sort ube2c drives human cervical cancer progression and is positively modulated by mtor
publisher MDPI AG
series Biomolecules
issn 2218-273X
publishDate 2021-12-01
description Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.
topic UBE2C
human papillomavirus
cervical cancer
bioinformation
url https://www.mdpi.com/2218-273X/11/1/37
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