UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors,...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/1/37 |
id |
doaj-4b0a5e8d4b914cdfa9b0bce36346d856 |
---|---|
record_format |
Article |
spelling |
doaj-4b0a5e8d4b914cdfa9b0bce36346d8562020-12-31T00:00:44ZengMDPI AGBiomolecules2218-273X2021-12-0111373710.3390/biom11010037UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTORAn-Jen Chiang0Chia-Jung Li1Kuan-Hao Tsui2Chung Chang3Yuan-chin Ivan Chang4Li-Wen Chen5Tsung-Hsien Chang6Jim Jinn-Chyuan Sheu7Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Applied Mathematics, National Sun Yat-sen University, Kaohsiung 804, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei 115, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114, TaiwanInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, TaiwanCervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.https://www.mdpi.com/2218-273X/11/1/37UBE2Chuman papillomaviruscervical cancerbioinformation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
An-Jen Chiang Chia-Jung Li Kuan-Hao Tsui Chung Chang Yuan-chin Ivan Chang Li-Wen Chen Tsung-Hsien Chang Jim Jinn-Chyuan Sheu |
spellingShingle |
An-Jen Chiang Chia-Jung Li Kuan-Hao Tsui Chung Chang Yuan-chin Ivan Chang Li-Wen Chen Tsung-Hsien Chang Jim Jinn-Chyuan Sheu UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR Biomolecules UBE2C human papillomavirus cervical cancer bioinformation |
author_facet |
An-Jen Chiang Chia-Jung Li Kuan-Hao Tsui Chung Chang Yuan-chin Ivan Chang Li-Wen Chen Tsung-Hsien Chang Jim Jinn-Chyuan Sheu |
author_sort |
An-Jen Chiang |
title |
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR |
title_short |
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR |
title_full |
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR |
title_fullStr |
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR |
title_full_unstemmed |
UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR |
title_sort |
ube2c drives human cervical cancer progression and is positively modulated by mtor |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-12-01 |
description |
Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment. |
topic |
UBE2C human papillomavirus cervical cancer bioinformation |
url |
https://www.mdpi.com/2218-273X/11/1/37 |
work_keys_str_mv |
AT anjenchiang ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT chiajungli ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT kuanhaotsui ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT chungchang ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT yuanchinivanchang ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT liwenchen ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT tsunghsienchang ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor AT jimjinnchyuansheu ube2cdriveshumancervicalcancerprogressionandispositivelymodulatedbymtor |
_version_ |
1724365524344766464 |