Formulation optimization of chitosan nanoparticles incorporated rabies viral antigen and its influence on the release kinetics, immune potency and biosafety potential

Formulation optimization of chitosan nanoparticles incorporated rabies viral antigen and its influence on the release kinetics, immune potency and biosafety potential

In the present study, optimization of parameters for the preparation of nano formulated whole attenuated rabies vaccine with high immune potency and biocompatibility was synthesised. Response Surface Methodology (RSM) was adapted to study the influence of factors such as the concentration of chitosa...

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Bibliographic Details
Main Authors: S. Karthick Raja Namasivayam, S. Kiran Nivedh, R.S. Arvind Bharani, Jeyanthi Rebecca, A.N. Nishanth
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Carbohydrate Polymer Technologies and Applications
Subjects:
Vaccine
Chitosan
Rabies
RSM
Release kinetics
Biocompatibility
Online Access:http://www.sciencedirect.com/science/article/pii/S2666893921000645

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