Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVH...
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Bibliographic Details
| Main Authors: |
Ruishu Deng,
Christian Hurtz,
Qingxiao Song,
Chanyu Yue,
Gang Xiao,
Hua Yu,
Xiwei Wu,
Markus Muschen,
Stephen Forman,
Paul J. Martin,
Defu Zeng |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00880-2
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