ACNE AND SYSTEMIC DISEASES

• Main Authors: Tugba Kevser Uzuncakmak, Ayse Serap Karadag, Necmettin Akdeniz
• Format: Article
• Language: English
• Published: European Medical Journal 2015-11-01
• Series: European Medical Journal Dermatology
• Subjects: acne; systemic diseases; insulin resistance; pyoderma gangrenosum; behçet’s syndrome
• Online Access: https://www.emjreviews.com/dermatology/article/acne-and-systemic-diseases/

Acne is a very common, multifactorial, complex, and chronic disease of the pilosebaceous unit that affects approximately 85% of adolescent patients and 3% of adult patients. The roles of sebaceous glands, androgens, follicular epithelial cells, Propionibacterium acnes , immune mediators, environmental factors, and genetic factors are well known in acne pathogenesis. Although it is not a life-threatening disease, it is closely associated with low quality of life and psychological depression. Moreover, acne can also be associated with hypovitaminosis, or may present as a part of systemic syndromes such as: congenital adrenal hyperplasia; seborrhoea-acne-hirsutism-androgenetic alopecia syndrome; polycystic ovary syndrome; hyperandrogenaemia, insulin resistance, and acanthosis nigricans syndrome; Apert syndrome; synovitis-acne-pustulosis-hyperostosis-osteitis syndrome; pyogenic arthritis, pyoderma gangrenosum, and acne syndrome; metabolic syndromes; and Behçet’s syndrome. These syndromes must be excluded in patients with severe and recalcitrant acne.