Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

Transient receptor potential melastatin 2 (TRPM2) is an important ion channel that represents a potential target for treating injury caused by cerebral ischemia. However, it is unclear whether reducing TRPM2 expression can help repair cerebral injury, and if so what the mechanism underlying this pro...

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Bibliographic Details
Main Authors: Tao Pan, Qiu-Jiao Zhu, Li-Xiao Xu, Xin Ding, Jian-Qin Li, Bin Sun, Jun Hua, Xing Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; calcium; caspase-1; nlrp3; mitochondrial impairment; oxidative stress; oxygen-glucose deprivation; pc12; shrna; trpm2
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2154;epage=2161;aulast=Pan

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