PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

<p>Abstract</p> <p>Background</p> <p>This study investigated variation in <it>NR1I2</it> and <it>NR1I3</it> and its effect on plasma efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led research on identifying...

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Bibliographic Details
Main Authors: Swart Marelize, Whitehorn Heather, Ren Yuan, Smith Peter, Ramesar Rajkumar S, Dandara Collet
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Medical Genetics
Subjects:
CAR
Efavirenz
HIV/AIDS
PXR
Pharmacogenetics
South Africa
Online Access:http://www.biomedcentral.com/1471-2350/13/112

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