<i>GSTM1</i> and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload

<i>GSTM1</i> and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload

Chronic blood transfusions in patients with sickle cell anemia (SCA) cause iron overload, which occurs with a degree of interpatient variability in serum ferritin and liver iron content (LIC). Reasons for this variability are unclear and may be influenced by genes that regulate iron metabolism. We e...

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Bibliographic Details
Main Authors: Latika Puri, Jonathan M. Flanagan, Guolian Kang, Juan Ding, Wenjian Bi, Beth M. McCarville, Ralf B. Loeffler, Aaryani Tipirneni-Sajja, Martha Villavicencio, Kristine R. Crews, Claudia M. Hillenbrand, Jane S. Hankins
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Journal of Clinical Medicine
Subjects:
sickle cell anemia
iron overload
glutathione s-transferase m1 (gstm1)
chelation therapy
Online Access:https://www.mdpi.com/2077-0383/8/11/1878

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