Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis

Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis

Epidemiological studies have shown an association between hypertension and knee osteoarthritis (OA). The purpose of this study was to investigate whether activation of the renin–angiotensin system (RAS) can aggravate mechanical loading-induced knee OA in mice. Eight-week-old male Tsukuba hypertensi...

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Bibliographic Details
Main Authors: Kotaro Yamagishi, Ichiro Tsukamoto, Fumihisa Nakamura, Kazuhiko Hashimoto, Kazuhiro Ohtani, Masao Akagi
Format: Article
Language:English
Published: PAGEPress Publications 2018-07-01
Series:European Journal of Histochemistry
Subjects:
Osteoarthritis
hypertension
RAS
AT1R
mechanical stress.
Online Access:https://ejh.it/index.php/ejh/article/view/2930

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