Large-Scale Analyses of Site-Specific Evolutionary Rates across Eukaryote Proteomes Reveal Confounding Interactions between Intrinsic Disorder, Secondary Structure, and Functional Domains

Large-Scale Analyses of Site-Specific Evolutionary Rates across Eukaryote Proteomes Reveal Confounding Interactions between Intrinsic Disorder, Secondary Structure, and Functional Domains

Various structural and functional constraints govern the evolution of protein sequences. As a result, the relative rates of amino acid replacement among sites within a protein can vary significantly. Previous large-scale work on Metazoan (Animal) protein sequence alignments indicated that amino acid...

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Bibliographic Details
Main Authors: Joseph B. Ahrens, Jordon Rahaman, Jessica Siltberg-Liberles
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Genes
Subjects:
evolutionary rates
protein sequence
intrinsic disorder
structural prediction
Eukaryotes
Online Access:https://www.mdpi.com/2073-4425/9/11/553

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