A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life

Overactive bladder (OAB) has become an increasing field of interest. Traditional use indicates that pumpkin seed (Cucurbita pepo L.) may be helpful in combating its symptoms. Additionally, soy isoflavones (Glycine max) are well-documented for hormonal imbalance related indications. The present rando...

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Main Authors:	Bongseok Shim, Hyewon Jeong, Sara Lee, Sehee Hwang, Byeongseok Moon, Charlotte Storni
Format:	Article
Language:	English
Published:	Elsevier 2014-05-01
Series:	Journal of Functional Foods
Subjects:	Pumpkin Cucurbita pepo Soy germ Incontinence Overactive bladder Clinical study
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464614000826

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spelling	doaj-4a981b01713c42ce8b4a0a53e58ad2322021-04-29T04:42:23ZengElsevierJournal of Functional Foods1756-46462014-05-018111117A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of lifeBongseok Shim0Hyewon Jeong1Sara Lee2Sehee Hwang3Byeongseok Moon4Charlotte Storni5Department of Urology, Medical Graduate School, Ehwa Woman's University, South KoreaDepartment of Obstetrics and Gynecology, Medical Graduate School, Ehwa Woman's University, South KoreaDepartment of Obstetrics and Gynecology, Medical Graduate School, Ehwa Woman's University, South KoreaNutraceuticals & Functional Foods Division, CJ Foods R&D, CJ Cheil Chedang, South KoreaNutraceuticals & Functional Foods Division, CJ Foods R&D, CJ Cheil Chedang, South KoreaFrutarom Switzerland Ltd, Rütiwisstrasse 7,8820 Wädenswil, Switzerland; Corresponding author. Tel.: +41 44 782 64 64; Fax: +41 44 782 64 66.Overactive bladder (OAB) has become an increasing field of interest. Traditional use indicates that pumpkin seed (Cucurbita pepo L.) may be helpful in combating its symptoms. Additionally, soy isoflavones (Glycine max) are well-documented for hormonal imbalance related indications. The present randomized, double-blind, placebo-controlled study evaluated efficacy and safety of Cucuflavone (containing extracts of pumpkin seed and soy germ) in 120 subjects suffering from OAB. After 12 weeks, subjects taking Cucuflavone experienced a significant reduction versus baseline, in (1) urination frequency, (2) urgency, (3) incontinence frequency, maximum urgency score, (5) nocturnal urination frequency and (6) OAB-symptom scale. The placebo group reached significant differences for (1), (3) and (6). No adverse events or abnormal changes in safety parameters occurred. Thus, the combination of pumpkin seed and soy germ extract can be used as natural alternative to relieve symptoms of OAB and to improve quality of life.http://www.sciencedirect.com/science/article/pii/S1756464614000826PumpkinCucurbita pepoSoy germIncontinenceOveractive bladderClinical study
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bongseok Shim Hyewon Jeong Sara Lee Sehee Hwang Byeongseok Moon Charlotte Storni
spellingShingle	Bongseok Shim Hyewon Jeong Sara Lee Sehee Hwang Byeongseok Moon Charlotte Storni A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life Journal of Functional Foods Pumpkin Cucurbita pepo Soy germ Incontinence Overactive bladder Clinical study
author_facet	Bongseok Shim Hyewon Jeong Sara Lee Sehee Hwang Byeongseok Moon Charlotte Storni
author_sort	Bongseok Shim
title	A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
title_short	A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
title_full	A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
title_fullStr	A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
title_full_unstemmed	A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
title_sort	randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2014-05-01
description	Overactive bladder (OAB) has become an increasing field of interest. Traditional use indicates that pumpkin seed (Cucurbita pepo L.) may be helpful in combating its symptoms. Additionally, soy isoflavones (Glycine max) are well-documented for hormonal imbalance related indications. The present randomized, double-blind, placebo-controlled study evaluated efficacy and safety of Cucuflavone (containing extracts of pumpkin seed and soy germ) in 120 subjects suffering from OAB. After 12 weeks, subjects taking Cucuflavone experienced a significant reduction versus baseline, in (1) urination frequency, (2) urgency, (3) incontinence frequency, maximum urgency score, (5) nocturnal urination frequency and (6) OAB-symptom scale. The placebo group reached significant differences for (1), (3) and (6). No adverse events or abnormal changes in safety parameters occurred. Thus, the combination of pumpkin seed and soy germ extract can be used as natural alternative to relieve symptoms of OAB and to improve quality of life.
topic	Pumpkin Cucurbita pepo Soy germ Incontinence Overactive bladder Clinical study
url	http://www.sciencedirect.com/science/article/pii/S1756464614000826
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A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life

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