Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury

Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury

Background and Aims: Fibroblast growth factor (FGF) 21 has recently been shown to play a potential role in bile acid metabolism. We aimed to investigate the FGF21 response in an ethanol-induced acute-on-chronic liver injury (ACLI) model in <i>Abcb4<sup>−/−</sup></i> mice with...

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Bibliographic Details
Main Authors: Grigorios Christidis, Ersin Karatayli, Rabea A. Hall, Susanne N. Weber, Matthias C. Reichert, Mathias Hohl, Sen Qiao, Ulrich Boehm, Dieter Lütjohann, Frank Lammert, Senem Ceren Karatayli
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
acute-on-chronic liver failure (ACLF)
alcohol-associated liver disease (AALD)
ATP binding cassette subfamily B member 4 (<i>Abcb4</i>) knock-out mouse
bile acid
cholesterol 7α-hydroxylase (Cyp7A1)
fibroblast growth factor 21 (FGF21)
Online Access:https://www.mdpi.com/1422-0067/22/15/7898

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https://www.mdpi.com/1422-0067/22/15/7898

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