Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents

Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents

A series of artemisinin-indoloquinoline hybrids were designed and synthesized in an attempt to develop potent and selective anti-tumor agents. Compounds 7a–7f, 8 and 9 were prepared and characterized. Their antiproliferative activities against MV4-11, HCT-116, A549, and BALB/3T3 cell lines in vitro...

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Bibliographic Details
Main Authors: Li Wang, Marta Świtalska, Ning Wang, Zhen-Jun Du, Yuta Fukumoto, Nguyen Kim Diep, Ryo Kiguchi, Junzo Nokami, Joanna Wietrzyk, Tsutomu Inokuchi
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
artemisinin
indoloquinoline
hybrid
antiproliferative activity
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/19/11/19021

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