Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target

Y-box binding protein 1 (YB-1) is an imperative biomarker for the clinical out-come of cancer patients. An overexpression of YB-1 in cancerous and adjoining tissues is an indication of aggressiveness and advanced stages. In normal resting cells, YB-1 is localized in cytoplasm while in stress conditi...

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Main Authors:	Vinoth Prasanna Gunasekaran, Kumari Nishi, Vilwanathan Ravikumar, Ganeshan Mathan
Format:	Article
Language:	English
Published:	Bangladesh Pharmacological Society 2016-04-01
Series:	Bangladesh Journal of Pharmacology
Subjects:	Cancer Nuclear shuttling Y-box binding protein 1
Online Access:	https://www.banglajol.info/index.php/BJP/article/view/26759

id	doaj-4a893e2cc913479c801faf2b634defa4
record_format	Article
spelling	doaj-4a893e2cc913479c801faf2b634defa42020-11-24T22:04:53ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-04-0111210.3329/bjp.v11i2.26759Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic targetVinoth Prasanna Gunasekaran0Kumari Nishi1Vilwanathan Ravikumar2Ganeshan Mathan3Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, TamilnaduDepartment of Biomedical Science, Bharathidasan University, Tiruchirappalli, TamilnaduDepartment of Biochemistry, Bharathidasan University, Tiruchirappalli, TamilnaduDepartment of Biomedical Science, Bharathidasan University, Tiruchirappalli, TamilnaduY-box binding protein 1 (YB-1) is an imperative biomarker for the clinical out-come of cancer patients. An overexpression of YB-1 in cancerous and adjoining tissues is an indication of aggressiveness and advanced stages. In normal resting cells, YB-1 is localized in cytoplasm while in stress conditions like cancer, nuclear shuttling of YB-1 takes place. In this review, the clinical importance of YB-1 in different cancers and the mechanism behind YB-1 nuclear shuttling have been discussed in detail. Targeted chemotherapies or molecularly targeted drugs of great importance can target and block specific molecules implicated in tumor growth and progression. YB-1 has been considered as a bonafide oncogene and accumulating evidences show the therapeutic importance of YB-1. Therapeutic strategies targeting YB-1 may improve the survival rate in cancer patients. This review extensively discusses the therapeutic importance of YB-1. https://www.banglajol.info/index.php/BJP/article/view/26759CancerNuclear shuttlingY-box binding protein 1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vinoth Prasanna Gunasekaran Kumari Nishi Vilwanathan Ravikumar Ganeshan Mathan
spellingShingle	Vinoth Prasanna Gunasekaran Kumari Nishi Vilwanathan Ravikumar Ganeshan Mathan Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target Bangladesh Journal of Pharmacology Cancer Nuclear shuttling Y-box binding protein 1
author_facet	Vinoth Prasanna Gunasekaran Kumari Nishi Vilwanathan Ravikumar Ganeshan Mathan
author_sort	Vinoth Prasanna Gunasekaran
title	Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target
title_short	Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target
title_full	Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target
title_fullStr	Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target
title_full_unstemmed	Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target
title_sort	nuclear shuttling of y box binding protein-1, its clinical relevance in cancer and as a therapeutic target
publisher	Bangladesh Pharmacological Society
series	Bangladesh Journal of Pharmacology
issn	1991-0088
publishDate	2016-04-01
description	Y-box binding protein 1 (YB-1) is an imperative biomarker for the clinical out-come of cancer patients. An overexpression of YB-1 in cancerous and adjoining tissues is an indication of aggressiveness and advanced stages. In normal resting cells, YB-1 is localized in cytoplasm while in stress conditions like cancer, nuclear shuttling of YB-1 takes place. In this review, the clinical importance of YB-1 in different cancers and the mechanism behind YB-1 nuclear shuttling have been discussed in detail. Targeted chemotherapies or molecularly targeted drugs of great importance can target and block specific molecules implicated in tumor growth and progression. YB-1 has been considered as a bonafide oncogene and accumulating evidences show the therapeutic importance of YB-1. Therapeutic strategies targeting YB-1 may improve the survival rate in cancer patients. This review extensively discusses the therapeutic importance of YB-1.
topic	Cancer Nuclear shuttling Y-box binding protein 1
url	https://www.banglajol.info/index.php/BJP/article/view/26759
work_keys_str_mv	AT vinothprasannagunasekaran nuclearshuttlingofyboxbindingprotein1itsclinicalrelevanceincancerandasatherapeutictarget AT kumarinishi nuclearshuttlingofyboxbindingprotein1itsclinicalrelevanceincancerandasatherapeutictarget AT vilwanathanravikumar nuclearshuttlingofyboxbindingprotein1itsclinicalrelevanceincancerandasatherapeutictarget AT ganeshanmathan nuclearshuttlingofyboxbindingprotein1itsclinicalrelevanceincancerandasatherapeutictarget
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Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target

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