Loop competition and extrusion model predicts CTCF interaction specificity

Loop competition and extrusion model predicts CTCF interaction specificity

Boundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.

Bibliographic Details
Main Authors: Wang Xi, Michael A. Beer
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21368-0
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spelling doaj-4a7e3fcaccb741f6871932d44d8598bb2021-02-21T12:12:40ZengNature Publishing GroupNature Communications2041-17232021-02-0112111510.1038/s41467-021-21368-0Loop competition and extrusion model predicts CTCF interaction specificityWang Xi0Michael A. Beer1Department of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineBoundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.https://doi.org/10.1038/s41467-021-21368-0
collection DOAJ
language English
format Article
sources DOAJ
author Wang Xi
Michael A. Beer
spellingShingle Wang Xi
Michael A. Beer
Loop competition and extrusion model predicts CTCF interaction specificity
Nature Communications
author_facet Wang Xi
Michael A. Beer
author_sort Wang Xi
title Loop competition and extrusion model predicts CTCF interaction specificity
title_short Loop competition and extrusion model predicts CTCF interaction specificity
title_full Loop competition and extrusion model predicts CTCF interaction specificity
title_fullStr Loop competition and extrusion model predicts CTCF interaction specificity
title_full_unstemmed Loop competition and extrusion model predicts CTCF interaction specificity
title_sort loop competition and extrusion model predicts ctcf interaction specificity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Boundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.
url https://doi.org/10.1038/s41467-021-21368-0
work_keys_str_mv AT wangxi loopcompetitionandextrusionmodelpredictsctcfinteractionspecificity
AT michaelabeer loopcompetitionandextrusionmodelpredictsctcfinteractionspecificity
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