Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus

Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus

Traumatic brain injury (TBI) increases the risk of delayed neurodegenerative processes, including Parkinson’s disease (PD). Interleukin-1beta (IL-1β), a key pro-inflammatory cytokine, may promote secondary injury development after TBI. Conversely, neutralizing IL-1β was f...

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Bibliographic Details
Main Authors: Ilknur Ozen, Karsten Ruscher, Robert Nilsson, Johanna Flygt, Fredrik Clausen, Niklas Marklund
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
traumatic brain injury
interleukin-1β
inflammation
parkinson’s disease
globus pallidus
axonal injury
Online Access:https://www.mdpi.com/1422-0067/21/2/387

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