Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature

Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature

Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a pat...

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Main Authors: Gunjan Shah, Hanah Yamin, Hedy Smith
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2013/130978
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spelling doaj-4a779b1af032426d97307d91dcd160282020-11-24T22:42:41ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/130978130978Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the LiteratureGunjan Shah0Hanah Yamin1Hedy Smith2Tufts Medical Center, 800 Washington Street, P.O. Box 245, Boston, MA 02108, USAJordan Hospital, 275 Sandwich Street, Plymouth, MA 02360, USATufts Medical Center, 800 Washington Street, P.O. Box 245, Boston, MA 02108, USAMicroangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery.http://dx.doi.org/10.1155/2013/130978
collection DOAJ
language English
format Article
sources DOAJ
author Gunjan Shah
Hanah Yamin
Hedy Smith
spellingShingle Gunjan Shah
Hanah Yamin
Hedy Smith
Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
Case Reports in Hematology
author_facet Gunjan Shah
Hanah Yamin
Hedy Smith
author_sort Gunjan Shah
title Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_short Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_full Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_fullStr Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_full_unstemmed Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_sort mitomycin-c-induced ttp/hus treated successfully with rituximab: case report and review of the literature
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2013-01-01
description Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery.
url http://dx.doi.org/10.1155/2013/130978
work_keys_str_mv AT gunjanshah mitomycincinducedttphustreatedsuccessfullywithrituximabcasereportandreviewoftheliterature
AT hanahyamin mitomycincinducedttphustreatedsuccessfullywithrituximabcasereportandreviewoftheliterature
AT hedysmith mitomycincinducedttphustreatedsuccessfullywithrituximabcasereportandreviewoftheliterature
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