NAD(P)-DEPENDENT DEHYDROGENASE ACTIVITY IN PERIPHERAL BLOOD LYMPHOCYTES OF INFANTS WITH ENLARGEMENT OF PHARYNGEAL TONSILS

• Main Authors: L. M. Kurtasova, A. R. Shmidt, T. V. Lubnina
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-08-01
• Series: Medicinskaâ Immunologiâ
• Subjects: lymphocytes; enzymes; pharyngeal tonsil enlargement
• Online Access: https://www.mimmun.ru/mimmun/article/view/705

We have observed and examined 57 children 1 to 3 years old diagnosed with enlargement of pharyngeal tonsils. A control group was presented by 35 healthy children. Bioluminescence technique was applied for studying NAD(P)-dependent dehydrogenase activity in peripheral blood lymphocytes. Activation of aerobic respiration and increasing activity of pentose phosphate cycle-dependent plastic processes were registered in blood lymphocytes of children with hypertrophic pharyngeal tonsils; along with decreased function of malate-aspartate shunt in energy metabolism of the cells, diminished anaerobic reaction of NADHdependent LDH, lower interaction between Krebs cycle and reactions of amino acid metabolism, and reduced activity of glutathione reductase.