Elevated Soluble PD-L1 in Pregnant Women's Serum Suppresses the Immune Reaction

Background: Programmed death-ligand 1 (PD-L1) is expressed not only on some cancer cells, but also on the outer surface of placental syncytiotrophoblasts, which is assumed to induce maternal immune tolerance to fetal tissue via programmed death-1 (PD-1) receptors on T cells. Recently, levels of solu...

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Bibliographic Details
Main Authors: Mai Okuyama, Hidetoshi Mezawa, Toshinao Kawai, Mitsuyoshi Urashima
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
MLC
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00086/full