MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation

MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation

Nuclear receptor coactivator 3 (NCOA3) is a transcriptional coactivator that has elevated expression in multiple tumor types, including colorectal cancer (CRC). However, the molecular mechanisms that regulate the tumorigenic functions of NCOA3 in CRC remain largely unknown. In this study, we aimed t...

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Bibliographic Details
Main Authors: Yixin Li, Liren Li, Miao Chen, Xinfa Yu, Zhuoyu Gu, Huijuan Qiu, Ge Qin, Qian Long, Xiaoyan Fu, Tianze Liu, Wenbin Li, Wenlin Huang, Dingbo Shi, Tiebang Kang, Meihua Luo, Xiaojun Wu, Wuguo Deng
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Molecular Oncology
Subjects:
colorectal cancer
degradation
MAD2L2
NCOA3
ubiquitination
Online Access:https://doi.org/10.1002/1878-0261.12173

Internet

https://doi.org/10.1002/1878-0261.12173

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