Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis

Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis

Cytoguardin was identified in the conditioned medium of fibroblasts as a tryptophan metabolite, 5-methoxytryptophan (5-MTP). It is synthesized via two enzymatic steps: tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). A truncated HIOMT isoform, HIOMT298, catalyzes 5-MTP syn...

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Bibliographic Details
Main Author:	Kenneth K. Wu
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	International Journal of Molecular Sciences
Subjects:	cytoguardin 5-methoxytryptophan cancer growth cancer metastasis cyclooxygenase-2 matrix metalloproteinase
Online Access:	https://www.mdpi.com/1422-0067/22/9/4490

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