Preoperative Microbiomes and Intestinal Barrier Function Can Differentiate Prodromal Alzheimer’s Disease From Normal Neurocognition in Elderly Patients Scheduled to Undergo Orthopedic Surgery

Preoperative Microbiomes and Intestinal Barrier Function Can Differentiate Prodromal Alzheimer’s Disease From Normal Neurocognition in Elderly Patients Scheduled to Undergo Orthopedic Surgery

ObjectiveEmerging evidence links perturbations in the microbiome to neurodegeneration in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) and to surgical stress. In this study, we attempted to identify preoperative differences intestinal microbiota (IM) and barrier function bet...

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Bibliographic Details
Main Authors: Mei Duan, Fangyan Liu, Huiqun Fu, Shibao Lu, Tianlong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
elderly patients
orthopedic surgery
preoperative period
prodromal Alzheimer’s disease
intestinal microbial dysbiosis
intestinal barrier dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.592842/full

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