Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.

Bibliographic Details
Main Authors: Chen Xu, Yan Zhang, Qiaoling Wang, Zhenyu Xu, Junfeng Jiang, Yuping Gao, Minzhi Gao, Jiuhong Kang, Minjuan Wu, Jun Xiong, Kaihong Ji, Wen Yuan, Yue Wang, Houqi Liu
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13287

Internet

https://doi.org/10.1038/ncomms13287

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