Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13287 |
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doaj-4a477c78d24844d0ad0f74749c74c2ce2021-05-11T10:34:55ZengNature Publishing GroupNature Communications2041-17232016-11-017111810.1038/ncomms13287Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signallingChen Xu0Yan Zhang1Qiaoling Wang2Zhenyu Xu3Junfeng Jiang4Yuping Gao5Minzhi Gao6Jiuhong Kang7Minjuan Wu8Jun Xiong9Kaihong Ji10Wen Yuan11Yue Wang12Houqi Liu13Research Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reprodutive Medcine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reprodutive Medcine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversitySchool of Life Sciences and Technology, Tongji UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityDepartment of Spine Surgery, Changzheng Hospital Affiliated to Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityResearch Center of Developmental Biology, Second Military Medical UniversityLong non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.https://doi.org/10.1038/ncomms13287 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chen Xu Yan Zhang Qiaoling Wang Zhenyu Xu Junfeng Jiang Yuping Gao Minzhi Gao Jiuhong Kang Minjuan Wu Jun Xiong Kaihong Ji Wen Yuan Yue Wang Houqi Liu |
| spellingShingle |
Chen Xu Yan Zhang Qiaoling Wang Zhenyu Xu Junfeng Jiang Yuping Gao Minzhi Gao Jiuhong Kang Minjuan Wu Jun Xiong Kaihong Ji Wen Yuan Yue Wang Houqi Liu Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling Nature Communications |
| author_facet |
Chen Xu Yan Zhang Qiaoling Wang Zhenyu Xu Junfeng Jiang Yuping Gao Minzhi Gao Jiuhong Kang Minjuan Wu Jun Xiong Kaihong Ji Wen Yuan Yue Wang Houqi Liu |
| author_sort |
Chen Xu |
| title |
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling |
| title_short |
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling |
| title_full |
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling |
| title_fullStr |
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling |
| title_full_unstemmed |
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling |
| title_sort |
long non-coding rna gas5 controls human embryonic stem cell self-renewal by maintaining nodal signalling |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs. |
| url |
https://doi.org/10.1038/ncomms13287 |
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