Risk factors for pyogenic cholangitis in patients with common bile duct stones

• Main Authors: WANG Chunqiu, MA Yingcai, ZHU Zhiyong
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2017-01-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=7943
• ISSN: 1001-5256; 1001-5256

ObjectivesTo investigate the early risk factors for pyogenic cholangitis in patients with common bile duct stones. MethodsThe clinical data of patients with common bile duct stones within 3 days after admission, who visited Qinghai Provincial People′s Hospital from January 2013 to June 2015, were collected, including sex, age, C-reactive protein (CRP), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), direct bilirubin (DBil), diameter of the common bile duct, diameter of the stones, oxygen partial pressure, and urobilinogen. The patients were divided into bile duct stone group and bile duct stone-pyogenic cholangitis group. The independent samples t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and the binary logistic regression was used for the screening for risk factors. ResultsThere were significant differences in sex, CRP, ALP, GGT, DBil, diameter of the common bile duct, oxygen partial pressure, and urobilinogen between the bile duct stone group and the bile duct stone-pyogenic cholangitis group (all P＜0.05). The binary logistic regression analysis showed that sex (OR=4.24, P＜0.001), CRP ≥3 mg/dl (OR = 2.39, P = 0.030), GGT≥224 U/L (OR=4.33, P＜0.001), ALP ≥198 U/L (OR=2.76, P=0.010), DBil ＞73 μmol/L (OR=2.57, P=0.020), diameter of the common bile duct ≥13 mm (OR=8.21, P＜0.001), oxygen partial pressure ＜80 mm Hg (OR=31.23, P＜0.001), and urobilinogen ≥2+ (OR=2.28, P＜0.001) were risk factors for pyogenic cholangitis in patients with common bile duct stones. ConclusionThe risk factors for pyogenic cholangitis in patients with common bile duct stones can be detected in early stage, which helps with the selection of surgical timing and procedure.