Heme-Dependent ER Stress Apoptosis: A Mechanism for the Selective Toxicity of the Dihydroartemisinin, NSC735847, in Colorectal Cancer Cells

Heme-Dependent ER Stress Apoptosis: A Mechanism for the Selective Toxicity of the Dihydroartemisinin, NSC735847, in Colorectal Cancer Cells

Colorectal cancer (CRC) is a leading cause of cancer death in the United States. Artemisinin derivatives, including the dihydroartemisinin (DHA) monomers, are widely used as clinical agents for the treatment of malaria. Numerous studies demonstrate that these molecules also display antineoplastic ac...

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Bibliographic Details
Main Authors: Ahmed E. M. Elhassanny, Eman Soliman, Mona Marie, Paul McGuire, Waseem Gul, Mahmoud ElSohly, Rukiyah Van Dross
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
artemisinin
colorectal cancer
selective toxicity
endoplasmic reticulum stress
reactive oxygen species
iron
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00965/full

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