Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury. Our laboratory has previously demonstrated that immunological demyelination of the CNS facilitates...

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Bibliographic Details
Main Authors: Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S. Keirstead
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/812456