Mitochondrial translocation of high mobility group box 1 facilitates LIM kinase 2-mediated programmed necrotic neuronal death

Mitochondrial translocation of high mobility group box 1 facilitates LIM kinase 2-mediated programmed necrotic neuronal death

High mobility group box 1 (HMGB1) acts a signaling molecule regulating a wide range of inflammatory responses in extracellular space. HMGB1 also stabilizes nucleosomal structure and facilitates gene transcription. Under pathophysiological conditions, nuclear HMGB1 is immediately transported to the c...

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Bibliographic Details
Main Authors: Hye-Won eHyun, Ah-Reum eKo, Tea-Cheon eKang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Epilepsy
seizure
Neuronal Death
mitochondrial fission
Leptomycin B
DRP1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00099/full

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