EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL
ABSTRACT BACKGROUND AND OBJECTIVE: Osteoarthritis is one of the most common joint diseases afflicting human, characterized by progressive degeneration of articular cartilage in which chondrocytes fails to adequately repair. Objective of this study is to evaluate the chondroprotection offered...
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University of Faisalabad
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doaj-4a26dd68452e4ae9948fd558cead68712021-05-27T01:04:32ZengUniversity of FaisalabadJournal of University Medical & Dental College2221-78272310-55422021-05-0112210.37723/jumdc.v12i2.463EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODELNoaman Ishaq0Quratulain Mehdi1Novera Sohail Bajwa2Shabana Ali3Bushra Shaheen4Muhammad Waqar Aslam Khan5Demonstrator, Department of Pharmacology Bakhtawar Amin Medical and Dental College, Multan.Post Graduate Trainee, Department of Pharmacology Army Medical College Rawalpindi.Post Graduate Trainee, Department of Pharmacology Army Medical College Rawalpindi.Assistant Professor, Department of Pharmacology Army Medical College Rawalpindi.Assistant Professor, Department of Pharmacology, Bakhtawar Amin Medical and Dental college, MultanAssociate Professor, Department of Pharmacology Army Medical College Rawalpindi. ABSTRACT BACKGROUND AND OBJECTIVE: Osteoarthritis is one of the most common joint diseases afflicting human, characterized by progressive degeneration of articular cartilage in which chondrocytes fails to adequately repair. Objective of this study is to evaluate the chondroprotection offered by triamcinolone in osteoarthritis induced rat model METHODOLOGY: This Laboratory based experimental study was conducted in Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of health, Islamabad from April-June2019. Osteoarthritis was induced by surgical removal of medial meniscus and anterior cruciate ligament resection in right knee joint of Sixteen (16) anesthetized rats of Sprague Dawley breed. They were divided in two (02) groups with eight (08) rats in each group. Group I was disease control in which 0.2 ml Intra articular saline was administered for three weeks. While group II was treatment group that was treated by 70 µl intra articular triamcinolone once weekly for three weeks. After that gait pattern of rats was scored. Animals were euthanized with over dosage of inhaled chloroform and sample of proximal tibia was taken for histopathological analysis. RESULTS: Mean gait score of control group and treatment group was 3.25±.707 and 2.25±.463 with a p value of .028 that is statistically significant. While mean histopathological modified Mankin score of control and treatment group was 11.5±1.195 and 8.5±1.195 respectively with a significant P-value of <0.01. CONCLUSION: Intra articular administration of triamcinolone in Osteoarthritis induced rats resulted in improvement in gait pattern and histopathology. Keywords: Chondroprotective efficacy, Osteoarthritis, Triamcinolone. http://www.jumdc.com/index.php/jumdc/article/view/463Chondroprotective efficacy, Osteoarthritis, Triamcinolone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Noaman Ishaq Quratulain Mehdi Novera Sohail Bajwa Shabana Ali Bushra Shaheen Muhammad Waqar Aslam Khan |
spellingShingle |
Noaman Ishaq Quratulain Mehdi Novera Sohail Bajwa Shabana Ali Bushra Shaheen Muhammad Waqar Aslam Khan EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL Journal of University Medical & Dental College Chondroprotective efficacy, Osteoarthritis, Triamcinolone |
author_facet |
Noaman Ishaq Quratulain Mehdi Novera Sohail Bajwa Shabana Ali Bushra Shaheen Muhammad Waqar Aslam Khan |
author_sort |
Noaman Ishaq |
title |
EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL |
title_short |
EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL |
title_full |
EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL |
title_fullStr |
EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL |
title_full_unstemmed |
EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL |
title_sort |
evaluation of chondroprotective efficacy of triamcinolone in osteoarthritis induced rat model |
publisher |
University of Faisalabad |
series |
Journal of University Medical & Dental College |
issn |
2221-7827 2310-5542 |
publishDate |
2021-05-01 |
description |
ABSTRACT
BACKGROUND AND OBJECTIVE:
Osteoarthritis is one of the most common joint diseases afflicting human, characterized by progressive degeneration of articular cartilage in which chondrocytes fails to adequately repair. Objective of this study is to evaluate the chondroprotection offered by triamcinolone in osteoarthritis induced rat model
METHODOLOGY:
This Laboratory based experimental study was conducted in Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of health, Islamabad from April-June2019. Osteoarthritis was induced by surgical removal of medial meniscus and anterior cruciate ligament resection in right knee joint of Sixteen (16) anesthetized rats of Sprague Dawley breed. They were divided in two (02) groups with eight (08) rats in each group. Group I was disease control in which 0.2 ml Intra articular saline was administered for three weeks. While group II was treatment group that was treated by 70 µl intra articular triamcinolone once weekly for three weeks. After that gait pattern of rats was scored. Animals were euthanized with over dosage of inhaled chloroform and sample of proximal tibia was taken for histopathological analysis.
RESULTS:
Mean gait score of control group and treatment group was 3.25±.707 and 2.25±.463 with a p value of .028 that is statistically significant. While mean histopathological modified Mankin score of control and treatment group was 11.5±1.195 and 8.5±1.195 respectively with a significant P-value of <0.01.
CONCLUSION:
Intra articular administration of triamcinolone in Osteoarthritis induced rats resulted in improvement in gait pattern and histopathology.
Keywords: Chondroprotective efficacy, Osteoarthritis, Triamcinolone.
|
topic |
Chondroprotective efficacy, Osteoarthritis, Triamcinolone |
url |
http://www.jumdc.com/index.php/jumdc/article/view/463 |
work_keys_str_mv |
AT noamanishaq evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel AT quratulainmehdi evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel AT noverasohailbajwa evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel AT shabanaali evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel AT bushrashaheen evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel AT muhammadwaqaraslamkhan evaluationofchondroprotectiveefficacyoftriamcinoloneinosteoarthritisinducedratmodel |
_version_ |
1721425973978595328 |