Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway.

Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway.

Renal reactive oxygen species (ROS) and mononuclear leukocyte infiltration are involved in the progressive stage (exacerbation) of IgA nephropathy (IgAN), which is characterized by glomerular proliferation and renal inflammation. The identification of the mechanism responsible for this critical stag...

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Bibliographic Details
Main Authors: Kuo-Feng Hua, Shun-Min Yang, Tzu-Yang Kao, Jia-Ming Chang, Hui-Ling Chen, Yung-Jen Tsai, Ann Chen, Sung-Sen Yang, Louis Kuoping Chao, Shuk-Man Ka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3810132?pdf=render

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