T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors

T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors

The dynamics of immunoaging and the onset of immunoparesis in healthy individuals and cancer patients has been controversially discussed. Moreover, the role of chemotherapy on T cell regeneration needs further elucidation in light of novel immunotherapies that have become standard of care for many e...

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Bibliographic Details
Main Authors: Donjete Simnica, Nuray Akyüz, Simon Schliffke, Malte Mohme, Lisa v.Wenserski, Thorben Mährle, Lorenzo F. Fanchi, Katrin Lamszus, Mascha Binder
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
immunoaging
immune reconstitution
ngs
tcr
diversity
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1644110

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