Zika Virus Vaccines: Challenges and Perspectives

Zika Virus Vaccines: Challenges and Perspectives

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led...

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Bibliographic Details
Main Authors: Raquel das Neves Almeida, Trina Racine, Kelly G. Magalhães, Gary P. Kobinger
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Vaccines
Subjects:
zika virus
flaviviruses
vaccines
animal models
immunopathology
immune responses
challenge
clinical trials
Online Access:http://www.mdpi.com/2076-393X/6/3/62
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spelling doaj-4a0f34b269ef4117b6bd5cf14083fd3f2020-11-24T21:41:37ZengMDPI AGVaccines2076-393X2018-09-01636210.3390/vaccines6030062vaccines6030062Zika Virus Vaccines: Challenges and PerspectivesRaquel das Neves Almeida0Trina Racine1Kelly G. Magalhães2Gary P. Kobinger3Laboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, BrazilCentre de Recherche en Infectiologie du CHU de Québec—Université Laval, Québec, QC G1V 4G2, CanadaLaboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, BrazilCentre de Recherche en Infectiologie du CHU de Québec—Université Laval, Québec, QC G1V 4G2, CanadaZika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.http://www.mdpi.com/2076-393X/6/3/62zika virusflavivirusesvaccinesanimal modelsimmunopathologyimmune responseschallengeclinical trials
collection DOAJ
language English
format Article
sources DOAJ
author Raquel das Neves Almeida
Trina Racine
Kelly G. Magalhães
Gary P. Kobinger
spellingShingle Raquel das Neves Almeida
Trina Racine
Kelly G. Magalhães
Gary P. Kobinger
Zika Virus Vaccines: Challenges and Perspectives
Vaccines
zika virus
flaviviruses
vaccines
animal models
immunopathology
immune responses
challenge
clinical trials
author_facet Raquel das Neves Almeida
Trina Racine
Kelly G. Magalhães
Gary P. Kobinger
author_sort Raquel das Neves Almeida
title Zika Virus Vaccines: Challenges and Perspectives
title_short Zika Virus Vaccines: Challenges and Perspectives
title_full Zika Virus Vaccines: Challenges and Perspectives
title_fullStr Zika Virus Vaccines: Challenges and Perspectives
title_full_unstemmed Zika Virus Vaccines: Challenges and Perspectives
title_sort zika virus vaccines: challenges and perspectives
publisher MDPI AG
series Vaccines
issn 2076-393X
publishDate 2018-09-01
description Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.
topic zika virus
flaviviruses
vaccines
animal models
immunopathology
immune responses
challenge
clinical trials
url http://www.mdpi.com/2076-393X/6/3/62
work_keys_str_mv AT raqueldasnevesalmeida zikavirusvaccineschallengesandperspectives
AT trinaracine zikavirusvaccineschallengesandperspectives
AT kellygmagalhaes zikavirusvaccineschallengesandperspectives
AT garypkobinger zikavirusvaccineschallengesandperspectives
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