Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

<p>Abstract</p> <p>Background</p> <p>Adipokines, e.g. TNFα, IL-6 and leptin increase insulin resistance, and consequent hyperinsulinaemia influences breast cancer progression. Beside its mitogenic effects, insulin may influence adipokine production from adipocyte stroma...

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Bibliographic Details
Main Authors: Grisouard Jean, Dembinski Kaethi, Mayer Doris, Keller Ulrich, Müller Beat, Christ-Crain Mirjam
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Diabetology & Metabolic Syndrome
Online Access:http://www.dmsjournal.com/content/3/1/16

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