Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease

• Main Authors: Stanković Aleksandra, Stanković Sanja, Jovanović-Marković Zagorka, Živković Maja, Đurić Tamara, Glišić-Milosavljević Sanja, Alavantić D.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2007-01-01
• Series: Archives of Biological Sciences
• Subjects: ApoB; ischemic cerebrovascular disease; gene; polymorphism; human population; Serbia
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2007/0354-46640704303S.pdf

The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (XbaI, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P<0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P<0.05). The patients had significantly higher frequency of the 4311A allele compared to the controls (P<0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.