High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion.

High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion.

The infusion of donor lymphocytes transduced with a retroviral vector expressing the HSV-TK suicide gene in patients undergoing hematopoietic stem cell transplantation for leukemia/lymphoma promotes immune reconstitution and prevents infections and graft-versus-host disease. Analysis of the clonal d...

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Bibliographic Details
Main Authors: Claudia Cattoglio, Giulietta Maruggi, Cynthia Bartholomae, Nirav Malani, Danilo Pellin, Fabienne Cocchiarella, Zulma Magnani, Fabio Ciceri, Alessandro Ambrosi, Christof von Kalle, Frederic D Bushman, Chiara Bonini, Manfred Schmidt, Fulvio Mavilio, Alessandra Recchia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3008730?pdf=render

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http://europepmc.org/articles/PMC3008730?pdf=render

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