Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin.

Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin.

Overexpression of the cellular FLICE-like inhibitory protein (cFLIP) has been reported in a number of tumor types. As an inactive procaspase-8 homologue, cFLIP is recruited to the intracellular assembly known as the Death Inducing Signaling Complex (DISC) where it inhibits apoptosis, leading to canc...

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Bibliographic Details
Main Authors: Gabriel Gaidos, Alexandra E Panaitiu, Bingqian Guo, Maria Pellegrini, Dale F Mierke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4631386?pdf=render

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