Central dogma rates and the trade-off between precision and economy in gene expression
The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07391-8 |
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doaj-49c76385217d4abdbed2391068e344b2 |
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Article |
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doaj-49c76385217d4abdbed2391068e344b22021-05-11T12:40:42ZengNature Publishing GroupNature Communications2041-17232019-01-0110111510.1038/s41467-018-07391-8Central dogma rates and the trade-off between precision and economy in gene expressionJean Hausser0Avi Mayo1Leeat Keren2Uri Alon3Department of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceThe same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.https://doi.org/10.1038/s41467-018-07391-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jean Hausser Avi Mayo Leeat Keren Uri Alon |
| spellingShingle |
Jean Hausser Avi Mayo Leeat Keren Uri Alon Central dogma rates and the trade-off between precision and economy in gene expression Nature Communications |
| author_facet |
Jean Hausser Avi Mayo Leeat Keren Uri Alon |
| author_sort |
Jean Hausser |
| title |
Central dogma rates and the trade-off between precision and economy in gene expression |
| title_short |
Central dogma rates and the trade-off between precision and economy in gene expression |
| title_full |
Central dogma rates and the trade-off between precision and economy in gene expression |
| title_fullStr |
Central dogma rates and the trade-off between precision and economy in gene expression |
| title_full_unstemmed |
Central dogma rates and the trade-off between precision and economy in gene expression |
| title_sort |
central dogma rates and the trade-off between precision and economy in gene expression |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-01-01 |
| description |
The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise. |
| url |
https://doi.org/10.1038/s41467-018-07391-8 |
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