Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant

Objective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity. Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The...

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Main Authors: M. Uday Kumar, M. Kishore Babu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-05-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2221169115302914
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spelling doaj-49bf892fbdce42e0b885c7b120ae7b7c2020-11-24T22:51:10ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-05-014S1S329S33410.12980/APJTB.4.2014B672Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrantM. Uday KumarM. Kishore BabuObjective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity. Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The swelling index and viscosity of fenugreek gum was 221% and 293.4 mpa.s respectively. FDTs of diclofenac sodium was formulated by direct compression technique using different concentrations (1%-6%, w/w) of fenugreek gum as a natural superdisintegrant and compared with renowned synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium. The anti-inflammatory activity of a formulation was evaluated with carrageenan induced experimental rats. Results: The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness and results complied with the limits. The drug release from all the formulations ascertained first order kinetics. Among all the formulations F3 containing fenugreek gum with the concentration of 6% produced least disintegrating time 21 seconds resulting in higher drug release rate 93.74% at the end of 25 min. Hence, it was considered as optimized formulation. The present study revealed that the fenugreek gum as a natural superdisintegrant showed better disintegrating property than the most widely used synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium in the formulations of FDTs. Conclusions: The results suggested that the fenugreek gum act as a good super disintegrating agent and it showed promising additive anti-inflammatory activity with diclofenac sodium.http://www.sciencedirect.com/science/article/pii/S2221169115302914Diclofenac sodiumFenugreek gumSuperdisintegrantAnti-inflammatory activitySodium starch glycolateCroscarmellose sodiumDirect compressionQuick pain relief
collection DOAJ
language English
format Article
sources DOAJ
author M. Uday Kumar
M. Kishore Babu
spellingShingle M. Uday Kumar
M. Kishore Babu
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
Asian Pacific Journal of Tropical Biomedicine
Diclofenac sodium
Fenugreek gum
Superdisintegrant
Anti-inflammatory activity
Sodium starch glycolate
Croscarmellose sodium
Direct compression
Quick pain relief
author_facet M. Uday Kumar
M. Kishore Babu
author_sort M. Uday Kumar
title Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
title_short Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
title_full Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
title_fullStr Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
title_full_unstemmed Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
title_sort design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
publisher Wolters Kluwer Medknow Publications
series Asian Pacific Journal of Tropical Biomedicine
issn 2221-1691
publishDate 2014-05-01
description Objective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity. Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The swelling index and viscosity of fenugreek gum was 221% and 293.4 mpa.s respectively. FDTs of diclofenac sodium was formulated by direct compression technique using different concentrations (1%-6%, w/w) of fenugreek gum as a natural superdisintegrant and compared with renowned synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium. The anti-inflammatory activity of a formulation was evaluated with carrageenan induced experimental rats. Results: The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness and results complied with the limits. The drug release from all the formulations ascertained first order kinetics. Among all the formulations F3 containing fenugreek gum with the concentration of 6% produced least disintegrating time 21 seconds resulting in higher drug release rate 93.74% at the end of 25 min. Hence, it was considered as optimized formulation. The present study revealed that the fenugreek gum as a natural superdisintegrant showed better disintegrating property than the most widely used synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium in the formulations of FDTs. Conclusions: The results suggested that the fenugreek gum act as a good super disintegrating agent and it showed promising additive anti-inflammatory activity with diclofenac sodium.
topic Diclofenac sodium
Fenugreek gum
Superdisintegrant
Anti-inflammatory activity
Sodium starch glycolate
Croscarmellose sodium
Direct compression
Quick pain relief
url http://www.sciencedirect.com/science/article/pii/S2221169115302914
work_keys_str_mv AT mudaykumar designandevaluationoffastdissolvingtabletscontainingdiclofenacsodiumusingfenugreekgumasanaturalsuperdisintegrant
AT mkishorebabu designandevaluationoffastdissolvingtabletscontainingdiclofenacsodiumusingfenugreekgumasanaturalsuperdisintegrant
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