Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant
Objective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity. Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The...
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Wolters Kluwer Medknow Publications
2014-05-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115302914 |
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doaj-49bf892fbdce42e0b885c7b120ae7b7c2020-11-24T22:51:10ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-05-014S1S329S33410.12980/APJTB.4.2014B672Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrantM. Uday KumarM. Kishore BabuObjective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity. Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The swelling index and viscosity of fenugreek gum was 221% and 293.4 mpa.s respectively. FDTs of diclofenac sodium was formulated by direct compression technique using different concentrations (1%-6%, w/w) of fenugreek gum as a natural superdisintegrant and compared with renowned synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium. The anti-inflammatory activity of a formulation was evaluated with carrageenan induced experimental rats. Results: The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness and results complied with the limits. The drug release from all the formulations ascertained first order kinetics. Among all the formulations F3 containing fenugreek gum with the concentration of 6% produced least disintegrating time 21 seconds resulting in higher drug release rate 93.74% at the end of 25 min. Hence, it was considered as optimized formulation. The present study revealed that the fenugreek gum as a natural superdisintegrant showed better disintegrating property than the most widely used synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium in the formulations of FDTs. Conclusions: The results suggested that the fenugreek gum act as a good super disintegrating agent and it showed promising additive anti-inflammatory activity with diclofenac sodium.http://www.sciencedirect.com/science/article/pii/S2221169115302914Diclofenac sodiumFenugreek gumSuperdisintegrantAnti-inflammatory activitySodium starch glycolateCroscarmellose sodiumDirect compressionQuick pain relief |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Uday Kumar M. Kishore Babu |
spellingShingle |
M. Uday Kumar M. Kishore Babu Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant Asian Pacific Journal of Tropical Biomedicine Diclofenac sodium Fenugreek gum Superdisintegrant Anti-inflammatory activity Sodium starch glycolate Croscarmellose sodium Direct compression Quick pain relief |
author_facet |
M. Uday Kumar M. Kishore Babu |
author_sort |
M. Uday Kumar |
title |
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
title_short |
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
title_full |
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
title_fullStr |
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
title_full_unstemmed |
Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
title_sort |
design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2221-1691 |
publishDate |
2014-05-01 |
description |
Objective: To formulate diclofenac sodium as fast dissolving tablets (FDTs) using fenugreek gum as a natural superdisintegrant which also possess anti-inflammatory activity.
Methods: An attempt was made to extract the fenugreek gum and evaluated it for various physicochemical characterizations. The swelling index and viscosity of fenugreek gum was 221% and 293.4 mpa.s respectively. FDTs of diclofenac sodium was formulated by direct compression technique using different concentrations (1%-6%, w/w) of fenugreek gum as a natural superdisintegrant and compared with renowned synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium. The anti-inflammatory activity of a formulation was evaluated with carrageenan induced experimental rats.
Results: The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness and results complied with the limits. The drug release from all the formulations ascertained first order kinetics. Among all the formulations F3 containing fenugreek gum with the concentration of 6% produced least disintegrating time 21 seconds resulting in higher drug release rate 93.74% at the end of 25 min. Hence, it was considered as optimized formulation. The present study revealed that the fenugreek gum as a natural superdisintegrant showed better disintegrating property than the most widely used synthetic superdisintegrants like sodium starch glycolate and croscarmellose sodium in the formulations of FDTs.
Conclusions: The results suggested that the fenugreek gum act as a good super disintegrating agent and it showed promising additive anti-inflammatory activity with diclofenac sodium. |
topic |
Diclofenac sodium Fenugreek gum Superdisintegrant Anti-inflammatory activity Sodium starch glycolate Croscarmellose sodium Direct compression Quick pain relief |
url |
http://www.sciencedirect.com/science/article/pii/S2221169115302914 |
work_keys_str_mv |
AT mudaykumar designandevaluationoffastdissolvingtabletscontainingdiclofenacsodiumusingfenugreekgumasanaturalsuperdisintegrant AT mkishorebabu designandevaluationoffastdissolvingtabletscontainingdiclofenacsodiumusingfenugreekgumasanaturalsuperdisintegrant |
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