The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK

In previous work, we characterized the strong neuroprotective properties of the marine compound Psammaplysene A (PA) in in vitro and in vivo models of neurodegeneration. Based on its strong neuroprotective activity, the current work attempts to identify the physical target of PA to gain mechanistic...

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Bibliographic Details
Main Authors: Marco Boccitto, Nayoung Lee, Satoshi Sakamoto, Lynn A. Spruce, Hiroshi Handa, Jon Clardy, Steven H. Seeholzer, Robert G. Kalb
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
Psammaplysene A
neurodegeneration
foxo
HNRNPK
RNA metabolism
Online Access:https://www.mdpi.com/1660-3397/15/8/246

Internet

https://www.mdpi.com/1660-3397/15/8/246

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