Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.

Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.

BACKGROUND & AIMS:Accumulating evidence suggests that retinol and its metabolites are closely associated with liver fibrogenesis. Recently, we demonstrated that genetic ablation of alcohol dehydrogenase 3 (ADH3), a retinol metabolizing gene that is expressed in hepatic stellate cells (HSCs) and...

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Main Authors: Hyon-Seung Yi, Hyuk Soo Eun, Young-Sun Lee, Ju Yeon Jung, Seol-Hee Park, Keun-Gyu Park, Hueng-Sik Choi, Jae Myoung Suh, Won-Il Jeong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0127946

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