Design and preparation of a novel colon-targeted tablet of hydrocortisone

• Main Authors: Yachao Ren, Lei Jiang, Shuman Yang, Sainan Gao, Hui Yu, Jie Hu, Dandan Hu, Wenbin Mao, Haisheng Peng, Yulong Zhou
• Format: Article
• Language: English
• Published: Universidade de São Paulo
• Series: Brazilian Journal of Pharmaceutical Sciences
• Subjects: Chitosan/gelatin complex film/drugs coating; Chitosan/multilayer coating system/drugs coating; Drugs/delivery system/colon-targeted; Tablets/bilayer-coated
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200239&lng=en&tlng=en

ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.