TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Interferons have been shown to mediate tumour rejection. Here, in a spontaneous mouse model of breast cancer, the authors show that this is disrupted owing to high levels of TGFβ produced in the tumour.

Bibliographic Details
Main Authors: Marion V. Guerin, Fabienne Regnier, Vincent Feuillet, Lene Vimeux, Julia M. Weiss, Georges Bismuth, Gregoire Altan-Bonnet, Thomas Guilbert, Maxime Thoreau, Veronica Finisguerra, Emmanuel Donnadieu, Alain Trautmann, Nadège Bercovici
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11998-w

Internet

https://doi.org/10.1038/s41467-019-11998-w

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