Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity

Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity

<p>Abstract</p> <p>Background</p> <p>Gain-of-function mutations of tyrosine kinase FLT3 are frequently found in acute myeloid leukemia (AML). This has made FLT3 an important marker for disease diagnosis and a highly attractive target for therapeutic drug development. Th...

Full description

Bibliographic Details
Main Authors: Chen Yun, Guo Yao, Han Jiayu, Ho Wanting, Li Shibo, Fu Xueqi, Zhao Zhizhuang
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Hematology & Oncology
Subjects:
Tyrosine kinase
FLT3
Activity assay
Inhibitor screening
Acute myeloid leukemia
Online Access:http://www.jhoonline.org/content/5/1/39

Internet

http://www.jhoonline.org/content/5/1/39

Similar Items